How Long Does It Take For Testosterone Troche To Work?

How Long Does It Take For Testosterone Troche To Work

How Long Does It Take For Testosterone Troche To Work?


Testosterone is a hormone that plays a crucial role in the development and maintenance of male reproductive tissues and characteristics. It is also present in females but in smaller amounts. Sometimes, individuals may experience low levels of testosterone, leading to various symptoms such as fatigue, decreased libido, and muscle weakness. To address this issue, healthcare providers may prescribe testosterone replacement therapy (TRT), which can come in different forms, including troches. In this article, we will explore testosterone troches, their mechanism of action, and how long it typically takes for them to work.

What are Testosterone Troches?

Testosterone troches, also known as lozenges or buccal tablets, are small, slow-dissolving tablets that are placed between the upper gum and cheek. These troches are designed to gradually release testosterone into the bloodstream over a period of time. They are a popular form of testosterone replacement therapy due to their ease of use and ability to bypass the liver, avoiding potential liver toxicity that can occur with other administration methods.

Mechanism of Action:

When a testosterone troche is placed in the mouth, it slowly dissolves, releasing testosterone. The testosterone is then absorbed through the mucous membranes of the mouth and enters the bloodstream. From there, it travels to various tissues in the body, where it binds to androgen receptors. This binding activates the androgen receptors and stimulates processes that are essential for maintaining optimal testosterone levels, such as protein synthesis and the development of male secondary sexual characteristics.

How Long Does It Take for Testosterone Troche to Work?

The time it takes for testosterone troches to work can vary from person to person. Factors such as individual metabolism, dosage, and frequency of use can influence the onset of effects. Generally, it may take a few weeks for individuals to start noticing the benefits of testosterone troches.

During the initial weeks of testosterone troche use, some individuals may experience an improvement in energy levels, mood, and libido. However, it is important to note that full benefits, such as increased muscle mass and strength, may take several months to become apparent. Patience is key when starting testosterone troche therapy, as it may require some time for the body to adjust and for hormone levels to stabilize.


To provide further clarity on testosterone troches and their effects, let’s address some frequently asked questions:

1. How often should testosterone troches be used?
– Testosterone troches are typically prescribed to be used once or twice daily, as directed by a healthcare provider. It is important to follow the specific dosing instructions provided.

2. Can testosterone troches be used by females?
– Testosterone troches can be prescribed for females, but the dosage and duration of therapy may differ from that of males. Women should consult with their healthcare provider to determine if testosterone replacement therapy is appropriate for their needs.

3. Are there any side effects associated with testosterone troche use?
– As with any medication, there is the potential for side effects. Common side effects of testosterone troche therapy can include acne, fluid retention, and increased red blood cell count. However, not everyone experiences these side effects, and they are typically mild and transient. It is important to discuss any concerns or side effects with a healthcare provider.

4. How long should testosterone troche therapy be continued?
– The duration of testosterone troche therapy can vary depending on the individual’s needs and the underlying cause of testosterone deficiency. Some individuals may require long-term therapy, while others may only need short-term treatment. It is important to work closely with a healthcare provider to determine the appropriate duration of therapy.

5. Can testosterone troches be used alongside other medications?
– It is important to inform your healthcare provider of all medications, supplements, and herbal remedies you are taking before starting testosterone troche therapy. Some medications can interact with testosterone, potentially affecting its effectiveness or causing adverse effects. Your healthcare provider will be able to advise you on any potential interactions.


Testosterone troches are a convenient and effective form of testosterone replacement therapy. They gradually release testosterone into the bloodstream, helping to address symptoms associated with low testosterone levels. While the exact time it takes for testosterone troches to work can vary, individuals can generally expect to experience improvements in energy, mood, and libido within a few weeks. Full benefits, such as increased muscle mass and strength, may take several months. As with any medication, it is important to follow the prescribed dosage and consult with a healthcare provider for personalized guidance and monitoring throughout the therapy.

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